Insulin sensitivity in the brain controls the distribution of fat
Unhealthy belly fat is often stubborn, and in many cases, also through Sport and healthy diet difficult to reduce. A German research team has now shown that the Insulin sensitivity of the brain, so the way the brain responds to Insulin, also depends significantly on where fat in the body attaches, and how badly affected persons of a lifestyle Intervention to benefit.
Researchers from the German center for diabetes research (DZD), the Helmholtz Zentrum München and the University hospital of Tübingen decrypted the connection between the fat distribution in the body and the Insulin sensitivity of the brain. The results were recently presented in the prestigious scientific journal “Nature Communications”.
Insulin sensitivity affects the distribution of adipose tissue
The more sensitive the brain responds to Insulin, the better a Person can maintain their weight, lose weight or unhealthy belly fat reduce. The brain responds by contrast, only little or not at all to the hormone, the sooner it comes to rapid weight gain and a continuous increase of visceral fat, i.e. fat tissue, that the internal organs accumulates. This is the Central results of the current research work.
Body fat in the abdomen is particularly unhealthy
As the scientist reports, scientists in the study, is the Position of the body fat is important for the validity of about how unhealthy fat is. Abdominal body fat is especially unhealthy, because visceral fat has a number of messenger substances are released. These messengers influence, the researchers reported, not only blood pressure, but also the release of the hormone Insulin. In addition, the messengers contribute to the onset of inflammation.
Under the skin fat rather harmless
Through these mechanisms, the risk for Diabetes, heart disease and certain types of cancer will be increased. Other fat tissue, as the subcutaneous fat under the skin, which legs, for example, on the bottom, top or hip attaches, have no known negative effects on health.
Why all people accumulate fat differently
Yet, it was not known why the fat storage of person-to-person is so different. The current study has come to this riddle solution now a big step closer. The results suggest that the effect of insulin in the brain plays an important role. So people with a high level of Insulin would, for example, sensitivity to benefit in the brain, significantly more of the life style interventions with a fibre-rich diet and exercise than people with Insulin resistance.
In the case of Insulin-resistance is increasing faster again
Data of 15 Participants were collected over a period of nine years, showed that a high Insulin sensitivity is directly associated with the reduction of Fat and in the weight. This showed that the distribution of adipose tissue is influenced by Insulin sensitivity. People with Insulin resistance in the brain showed to the Participants with a high Insulin sensitivity only in the first nine months of the program, a slight weight loss. “After that, the body weight and visceral fat increased during the following months of lifestyle Intervention,” says study first author Dr. Stephanie Kullmann.
Insulin sensitivity only affects visceral adipose tissue
In a further study of 112 Participants, the researchers showed that people with high Insulin sensitivity in the brain region, the Hypothalamus, only a little visceral fat tissue. On the formation of sub-dermal fat tissue, the Insulin sensitivity to have no effect.
A new mechanisms of fat distribution
“Our study shows a new mechanism that controls the distribution of fat in humans,” says the study’s head, Professor Dr. Martin Heni from the University hospital of Tübingen. Because visceral fat can not only play in the pathogenesis of type 2 Diabetes a role, but also the risk for heart disease and cancer increase, can offer the results of the study, perhaps also to new approaches for the treatment of metabolic diseases, the Director of research. (vb)
Read also: belly fat reduce: The best 25 methods.
Authors and source of information
This Text meets the requirements of the medical literature, medical guidelines, as well as current studies and was examined by doctors and Medical scientists.